On day 5 (Mon), we got the news that all 5 eggs were still alive but were growing at a slower rate. The latest version of the American Society for Reproductive Medicine (ASRM) Practice Committee publication states that "a single . (If you didn't have a day-5 transfer, your implantation window is 6 to 10 days after egg retrieval. Success Stories Motherhood at the age of 64 I am Mrs Our first attempt at IVF gave us a total of 8 blastocysts, however all of them were either Day 6 or Day 7 5% were transferred on day five, 4 Compared to embryo transfer at an early development stage (day 2 or 3) the odds are increased by around 7% (Source DIR Jahrbuch - German IVF-Registry Annual . Both had 4 cells, all cells were the same size and each cell had 1 nuclei! I took another test 8 days after my day-5 blastocyst transfer (2 days ago) and it was much darker in color, so things are looking even more promising. I had a morula transferred day 5 this week - bit of a rollercoaster of emotions- keep going from feeling hopeful to very unoptomistic. A: An embryo that has been growing for 3 days typically has 8 cells. My doctor had recommended transferring just 1 blastocyst. Day 5. If they could survive till 5days in petri dishthey got all the chances to survive in uterus. However, this is not the only reason for the arrest. 7 eggs retrieved, 6 mature, 5 fertilized. Sending some good luck wishes your way. Morula's and question about day 5 transfers. We see significantly higher blastocyst implantation and pregnancy rates as compared to what we see with day 3 embryos. poor quality blasts) have roughly 1/2 of the chance of a good quality embryo. Up to this point, embryonic development has been controlled by maternal genes in the oocyte. Take time off. Morula. With the second donor we ended up with 2 blasts. Here's what research conducted in 2019 shows for fresh and frozen embryo transfer success rates: Higher quality embryos are associated with a 79% live birth rate with good quality at 64%. We mean it. We had 8 eggs, 7 fertilized eggs and only two made it to day five morula. So we're trying to see if anyone had any success with a day five morula transfer. My doctor told me that the success rate with morulas on day 5 is just slightly less than blastocysts on day 5..some embryos just need an extra day to get to the blastocyst stage. This is also one to five days after a blastocyst transfer in the recipient. Day 5: embryo 3 morula by day 5 but poor quality and not good enough to freeze . However, I'm still having daily cramps that's very unnerving. IVF#2 . Laura tries to answer the question why IVF cycles fail and if modern science can do anything about it. We had the transfer. At the time, I remember thinking he just wanted our money (but 2 years later, I'm certainly less cynical) Well, our first cycle was a complete shock and very disappointing. RE: day 5 cavitating morulas on DE cycles Posted on: May 1, 2014 at 6:34am. We had 3 eggs fertilize in total. . I didn't have anymore to freeze as the rest stopped developing at day 3. 5 day transfer of 1 morula = BFN. Lower chances of a multiple pregnancy, as in many cases we can even opt to transfer 1 embryo. The Dr. suggested 3 egg transfer with the hope that at least 1 will catch. 1. A day 5 morula can become a day 6 blast but not high probability that is is good quality. 1. So by day 5, my doc explained that they like to see the embryos at the blastocyst stage. I am 32. . I am with shady grove and this is my third ivf. Wider implications of the findings: Fresh transfer of embryos that begin blastulation on Day 5 results in similar outcomes to the transfer of FEB originating from the same cohort. 1.According to the development of post-thawed embryos after overnight culture, embryos were assigned to a non-morula stage group (8-16 cells group, group I, n = 153), a one morula stage group (group II, n = 145), and a two morulae . By Day 5 (yesterday) we had two embryos that were okay and able to be transferred but they were a little behind. However, looking at the embryos this morning it turned out that my embryos had not quite reached blastocyst phase. We let it grow to day 6 and by the afternoon of day 6 it was an expanded blast. She said based on this report they wanted to grow them out to day-5 to see which ones come out the strongest and if any come up from behind. This means that high pregnancy rates can be achieved from the transfer of fewer embryos on day 5 with a reduction in the risk of high-order multiple gestations. using blastocyst transfer has increased our success rate to more than 80% per transfer. To my surprise 2 were great quality. Blastocyst transfer facilitates a high pregnancy rate and reduces the incidence of multiple pregnancy and ectopic pregnancy[1,2,3,4,5,6].Prolonged culture of the embryos to blastocyst stage has become the preferred method in most reproductive centers[5, 6].Prospective randomized controlled trials have reported a higher implantation rate(IR) and clinical pregnancy rate(CPR) in frozen-thawed . Hi ladies - I won't go through my whole story but will pick up with the last week. Well just like last cycle got to the clinic today to learn that 16 of our 18 embryos arrested between day 4-5, there were two embryos still growing but at day 5 they were only morula, one looks like it's starting to get the "fluid" like spot but just so devastated. She said that the 5 cell embryo could jump ahead, but it was . Day 5 or even later on day-4 brings the transformation of the ugly ducklingthe morulainto a swana blastocyst, consisting of anywhere from 30 to 200+ cells. Probably if you are 44, you will have only a few embryos. The primary benefit to the patient of using blastocyst stage embryo culture is that fewer embryos need be transferred into the patient because each day 5 embryo has a higher chance . we retrieved 15, 10 fertlized and only 4 . Five eggs were retrieved, 4 fertilized, and 3 were transferred. My doctor wasn't optimistic either but we have boy/girl twins! Cleavage stage embryos are graded using 2 criteria: the number of cells in the embryo and their appearance under a high-power microscope. Typically, a good, normally growing day 3 embryos will contain between 6 and 10 cells. Today is 07-07-10. We were out of money, and I felt like I was running out of time due to my age (I was 42 at the time), so I joined some support groups on Facebook. On Saturday (the 14th), I had my retrieval. The first one was a slow grower too, went to day 6, but with research I found out that it wasn't a bad thing and that more often than not it's a female embryo. Here's the data: Oron (2014) looked at single embryo transfers in women <40 years of age: Good quality blasts (3BB) a live birth rate of 41% was achieved My morulas were arresting, but my cycle buddy also had no blasts, transferred only one morula on day 5 (her transfer was immediately after mine), and she got her bfp. Today I received the day 5 update and all are still morula stage. I took another test 8 days after my day-5 blastocyst transfer (2 days ago) and it was much darker in color, so things are looking even more promising. By day 3 we still had 3 but 2 of them had only 3 and 4 cells respectively - the other was 7 which is considered "normal." This stage is the first time we see the cells begin to organize themselves. Some are slow growers, but that does not matter at all. Interestingly, when we compared the fair day 5 embryo quality group to the good and top day 6 embryo quality groups, day 5 embryos still exhibited significantly higher LBR (24.12% vs. 16.5%, P = 0 . As of todayI I'm 25+4 with boy/girl twins. I'm going through my 1st round of IVF. The sequence shown below shows an 8-cell embryo on day 3 (#1) in which the cells are beginning to press up against one another (see 2 cells flattening against each other). This is when the timing issue comes in a bump in progesterone is the trigger that tells the uterine lining that there's an embryo on the way. Morula transfers are marginally more successful than 3 day transfers and marginally less successful than a blasto transfer but from what I remember (from research I did myself when . Fragmentation: Embryos with no or little fragmentation are labeled grade A, those with more than 10% fragmentation are grade B, and the ones with more than 25% and 50% fragmentation are labeled C and D grade respectively. If you have a Day-3 transfer, you should have one or more embryos to transfer, and if you have a Day-5 transfer, you should have one or more blastocysts to transfer. 5 day morula transfer - any BFP success stories? In other words, she will be able to confirm whether she is pregnant and the treatment has been successful.. They were still in the Morula stage. Key Takeaway. Today is my 41st birthday. The freshly fertilized embryo is called a zygote. The 2PN zygote divides into an embryo (2-4 cells), the "morula" approx. I had a day 5 morula transferred back in 2018 and had my DD who is now 2.5. However they were good looking morulas with no fragmentation per dr.at fertility clinic but no blastocyst as of yet. The first Home Pregnancy Test I did was 5 days after my day-5 blastocyst transfer, which was positive. . . Previously we have transferred twice on day 3- one bfn and one chemical. My husband and I are 1st time ivf'ers and today was supposed to be our day 5 transfer of what we were hoping were going to be blastocyst. At this stage, he was expected to be a . Our Story Me- 35, mild hypothyroidism DH- 29, low count due to a chromosomal abnormality, only option is IVF/ICSI with PGD. By Day 5, the embryo, now called a blastocyst, is about 70-100 cells. At the blastocyst stages 2-6, the inner cell mass and trofectoderm class A or B had to be . We got 4 eggs, 2 fertilised but arrested by day 5. The Dr. had checked in the morning and by 2 pm, 1 egg was starting to show indications of moving to the next stage. KitKatKates Fri 22-Mar-19 16:03:11. . Any more success stories. The flow diagram for this study is shown in Fig. We've scoured the internet about the success of day five morula transfers but there hasn't been that much hope. Can't begin to describe the devastation on top of the grief of losing my own fertility. The first Home Pregnancy Test I did was 5 days after my day-5 blastocyst transfer, which was positive. The Dr. suggested 3 egg transfer with the hope that at least 1 will catch. . We had the transfer. This means that high pregnancy rates can be achieved from the transfer of fewer embryos on day 5 with a reduction in the risk of high-order multiple gestations. Cells divide into two groups: Inner cell mass - The group of cells that will become the embryo . Day 3. . The Embryo Transfer (ET) is the last step of the In Vitro Fertilization process.If the cycle has been a successful one, the patient will get a positive pregnancy test on day 15 post embryo transfer. 5 day transfer of 1 morula = BFN. Under the supervision of an embryologist, there is a range of growth . Just want to follow since I have one day six that is fully hacthed but was a Compacting Morula day 5 that Im thinking I may transfer. Embryo transfer day, a hurdle for every surrogacy journey. Day 1-3: the egg undergoes division in the solid morula stage. The cells of the morula continue to divide, developing into a blastocyst. Probably less than three, with 8 cells on day 3. To summarize, grade C embryo success rates (ie. Success stories? Implantation takes place 1 to 5 days after a blastocyst transfer. By Day 3, it is about 4-8 cells, and is referred to as a multicell embryo. They got 5 mature eggs and overnight, 3 matured. Stay Positive! All 6 made it through thaw, only 3 fertilized. Embryos with grade A and B are considered good and most likely to result in a healthy pregnancy. At day eight, the embryo will still sink in fluid, but . During an IVF cycle, an embryologist is responsible for the 6-day process to create and select the most promising embryos. My sweet baby was transferred on Day-5. After the first 24 hours, (Day 1) the embryo has divided into 2 cells. So you see your morula could become a blast at any point just because it's not a blast yet doesn't mean it's a whole day behind it may mearly be an hour or 2 behind. We had no blastocytes which was hugely disappointing. Today is 07-07-10. Determining the best day for the embryo transfer actually depends on the progression of . Day 2. We had 3 eggs fertilize in total. Sending some good luck wishes your way. This cycle also yielded 3 eggs, 2 fertilized, and only 1 made it to transfer as a day 5 morula. The recently formed blastocyst begins to hatch out of its shell. Our Story Me- 35, mild hypothyroidism DH- 29, low count due to a chromosomal abnormality, only option is IVF/ICSI with PGD. The embryo continues to grow and develop, turning from a 6-8 cell embryo into a morula. . The webinar is hosted by Laura Van Os, an embryologist from IVF Spain. We had 12 embryos progressing but sadly none were in a viable condition for transfer day 5 except for one murola. However, I'm still having daily cramps that's very unnerving. Morulas only on day 5. By Day 2, the embryo has 4 cells and by the third day, there should be 6-8 cells. When a couple has high-quality embryos available for transfer on day 5 and they are offered the options of transferring one embryo with a 50% expectation for pregnancy (almost all singles) or two embryos with an 75% expectation for pregnancy (about 38% twins, 60% single, and 2% triplets), most couples choose to transfer two embryos. My doctor seemed pretty bummed and gave us a 20% chance of pregnancy for each embryo. Day 5 Morula transfer through IVF. These success rates include all cycles in 2020 where: women used their own eggs for IVF treatment. Subject: Re:transfer of 3 embryos, mediocre quality - success stories? - Day 0: Mature egg is inseminated - Day 1: Fertilization assessment - Day 2: Embryo is between 2-4 cells - Day 3: Embryo is between 6-8 cells - Day 4: Embryo is compacting ( cell-to-cell adherence) or Morula (16-32 cells, cells adhered ) or cavitation (CAV) - Day 5-7: Embryo shows early cavitation (CAV) or becomes Blastocyst So here are 10 tips to improve your implantation prospects after an IVF cycle. Hello. All the cells are doing the same job and are identical at this point. Stellabelle #4 Validating 4 posts Posted 20 March 2008 - 07:55 AM Thank you to those who have replied to my post about a Morula day 5 transfer. If you have more than three, probably embryo on day 5 would be better; if you have less than 3 embryos, probably transfer on day 3 is the best option. The Dr. had checked in the morning and by 2 pm, 1 egg was starting to show indications of moving to the next stage. 1 - 5 cell fair. Once your day (either Day-3 or Day-5) approaches, get ready for a quick and painless transfer. Approximately 50% of the good quality embryos on day 3 will not survive until day 5, although those embryos that do survive have a good chance of implantation. This means the commonest reason of in vitro developmental arrest is a genetic problem, which prevents the growth of abnormal embryos. My RE advised the chances of success with a morula are about 15% vs 30% for a blast. Official diagnosis: Unexplained IF. 2. very little chance on question 2. Please help 07/16/2017 14:06 Subject: Morula transfer on day 5 . If you decide to have your embryos frozen or take part in a fresh embryo . However they were good looking morulas with no fragmentation per dr.at fertility clinic but no blastocyst as of yet. . Approximately 50% of the good quality embryos on day 3 will not survive until day 5, although those embryos that do survive have a good chance of implantation. Cal;l me if this does not work out I have some thoughts. Hey guys so i had embryo transfer 2 days ago.they didnt make it to blasts..instead I had 1 compacting morula and 1 cavitating morula (which i transferred both).can anyone tell me more about this..also has anyone had any success by transferring these ? . Anonymous: we also had et this morning and they said we didn't have blasts but morula and 8 cell embryo. Some patients are better served having . Around the 8 cell stage the embryonic genome is . A blastocyst has differentiated and contains two different cell . I am 32. . During the early growth of the multicell embryo, all of the energy and chemicals required for cell division come from the mother's egg. Day 3 transfer was . They were still in the Morula stage. It is important to point out that by culturing embryos . 13/06/2019 at 7:48 pm. Of 11 embryos (5 which were optimum at day 3), there were two at the early blastocyst phase (or possibly still morula phase). A total of 784 frozen-thawed embryos, in 392 hormonal replacement transfer cycles, were included in this study. By day 4 of life (#3) the embryo is completely . My husband and I are 1st time ivf'ers and today was supposed to be our day 5 transfer of what we were hoping were going to be blastocyst. As I have said before, it depends on the number of embryos on day 3 with 8 cells. By day 2 (transfer day) we had 5 remaining. Day 4. While the cell number is objective, the score for appearance is subjective using a score of 1-4. Take that week off. Our egg donor is an anonymous, healthy, 22 year old woman from a frozen egg bank. An embryo that continues to grow to Day 5 becomes a blastocyst with hundreds of cells. Everything about that round was shit but it . No day 5 blasts. Then, 2 to 3 days later, the embryo enters the uterus as a blastocyst, not a day 3 embryo, to attach and grow. A single cell embryo is called a 2PN zygote (for 2 pronuclei). IVF#2 . Transferring 2 day 5 embryos has a higher pregnancy rate and a 30 to 40% chance of twins. (20 Posts) Add message | Report. Worth it though because I've seen lots of woman on FF (fertilityfriendonline) tell success stories. I . Doctors said we'd most likely have a baby naturally eventually but that if we wanted 2 or 3 kids, we'd likely need IVF. But all are still growing. 2) Chromosomal abnormalities. 5 IUIs bfn, Miracle Natural bfp ended with cp, 1 ICSI bfn bcoz of ohss and first FET transferred 2blasts (1 early blast, 1 morula). Trying concieve since 40 1st IVF/ICSI age 41 : Gonal F 300; 3 eggs; 2 fertilised; transfer day 5; BFN 2nd IVF/ICSI age 42 : Menopur 425; 2 eggs; 2 fertislised; transfer day 5; BFN 3rd IVF age 42 : Short protocal Menopur 375; so far on Day 4 scan 2 focilles again and some very small ones Dont know what Hi All, This is my first time posting and was hoping for some other stories like mine. Here are our live birth success rates for day 5 blastocyst transfer cases: We have done blastocyst culture and transfer since 1998. I am a couple weeks from my 42nd birthday and I am trying my first round of IVF using donor eggs. Hi ladies, I have had a day 5 morula trasnfer on Monday and i am just looking for anybody that has positve or negative posts about going throguh this. Morula, 160 microns. During an in vitro fertilization (IVF) cycle, after the eggs are retrieved, they are fertilized in a lab, where they grow for up to 6 days. stage 3) by Day 6 . Days Past Transfer (DPT) Embryo Development. Hi all I am new in this forum I had EC yesterday I had 5 mature eggs collected and this morning i got a call from embryologist that only 1 got fertilised in a good way so he asked me to have a day 2 transfer now I never had day2 I have had day3 long time ago and day5 fresh and frozen this January which was failed cycle. By day eight, the embryo has increased in size to 800 microns or more and is termed a large expanded blastocyst. 16 - 32 cells) and finally a "blastocyst" embryo. This premature progesterone elevation signals the onset of the window of implantation. After about 16 hours, the cells have divided again to produce a 16-cell embryo (#2) and they have compacted together even more. Day 3 embryos are graded according to two criteria: Number of cells. . With embryo transfer it's important to keep an eye on each step of the embryos structure as well its likelihood of establishing pregnancy. We received a batch of 6 eggs. The pregnancy rates after transfer on day 3 or day 5 were equivalent, 66 and 71% respectively; however, significantly more embryos were transferred on day 3 (3.7) than on day 5 (2.2). Embryo Transfer Allowing the embryos to grow from Day 3 (cleavage stage) to Day 5/6 (blastocyst) allows us to select the embryos with the highest chance of success. On day 5 (Mon), we got the news that all 5 eggs were still alive but were growing at a slower rate. The success of the embryo transfer will depend on the quality of the embryos, but also on the state of the endometrium and its receptivity at the time of the transfer. 2 - 4 cell poor. It is the same size as an egg but the cells get smaller in size as they divide. Well just like last cycle got to the clinic today to learn that 16 of our 18 embryos arrested between day 4-5, there were two embryos still growing but at day 5 they were only morula, one looks like it's starting to get the "fluid" like spot but just so devastated. My current pregnancy was a morula on day 5. I froze it and transferred it on a frozen cycle and when they thawed it, it quickly hatched and became a fully hatched blast at transfer. 07/16/2017 13:44 Subject: Re:Morula transfer on day 5. Unfortunately, this embryo did not implant either. Posted 17/7/15 hi, I had my ET yesterday in day 5 and they transferred 2, they said they were a day behind their development, one was a compacting morula (the better one) and one was a morula. An embryo might undergo developmental arrest because of : 1) Sub-optimal culture conditions. A summary timeline of normal implantation follows: Day 0: the egg is fertilized high up in the fallopian tubes and forms the zona pellucida. I was absolutely stunned when I did the pregnancy test. Some doctors will tell you that they have more success with blastocyst embryos transferred at day five rather than morula embryos transferred at day 3. Official diagnosis: Unexplained IF. My RE advised the chances of success with a morula are about 15% vs 30% for a blast. This was the breakdown of our 9 embryos on day-3: 2 - 8 cell good. Embryo Quality and Failed IVF - 5 days in the IVF laboratory. So no I didn't transfer a day 5 morula but my successful embryo was a morula on day 5. Some of the advantages of performing an embryo transfer at the blastocyst stage, instead of on Day 2-3 of embryo culture are: Better selection of the fastest growing embryos. Minner27 10/05/22. on the 4th day, the embryo is in the morula stage and there is no reliable standardized assessment of this stage of development, so it is preferable to wait until it is a . The Day 5 embryos were evaluated according to Gardner and Schoolcraft. My egg retrieval was Wednesday. In the webinar she focuses on the 5-day period after the insemination when the embryo stays in culture. Somewhat subjective so two different embryologists may have two . I went for my day 5 embryo transfer today. Higher success rates. My partner and I did an embryo transfer this morning. M Momoftwos2015 Apr 4, 2015 at 7:44 PM @tracielinn, I had a 5 day FET of an early blast and a morula. 3 - 8 cell good- (minus) 1 - 9 cell good. Bottom line: Transferring 1 day 5 embryo (blastocyst) has almost the same pregnancy rate as transferring 2 day 3 embryos, and almost no chance of twins (compared to a 20% chance of twins transferring 2 day 3 embryos). Anonymous: Anyone??? Now, for women less than 35 years old, 47.2% of IVF cycles resulted in the birth of a single baby, while for women over 40 using their own eggs, 7.2% of IVF cycles resulted in the live birth of a single baby. Im feeling really negative about this and already feeling like it . An embryo was selected for cryopreservation by vitrification if it had reached at least a fully compacted morula stage by Day 5 or the true blastocyst stage (i.e. Kristiec78 28/05/13. 1. However, in cases where only morula/compacting embryos are available by Day 5, extending culture until FEB are achieved and then performing subsequent FET will result . On day 3, 3 had 8 cells and 2 had 6 but the lab said they were all good quality. Grade C blastocyst stage (Day 5+) success rates. but if I'm going to end up doing a morula at day 5, I'd prefer to do day 3 and get the embryos out of the lab.